Buprenorphin
Pflaster Transdermal, Fertigspritzen, Sublingualtabletten, Lyophilisat zum Einnehmen
Kurzübersicht
Erwachsene
DANI
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DALI
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Ältere Personen
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Wichtige Hinweise
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Schwangerschaft / Stillzeit
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Kinder und Jugendliche
Dosierung
Therapievorschlag: Buprenorphin (z.B. Temgesic®) 0,3–0,6 mg i.v./i.m. alle 6–8 Std., nach Bedarf Intervall verkürzen, bei schwerer Leberinsuffizienz kontraindiziert, ab GFR <30 mL/min vorsichtige Dosierung unter Kontrolle der Retentionsparameter
Therapievorschlag: Umstellung auf Depotpräparat gemäß folgender Dosisumrechnung: 2–6 mg Buprenorphin s.l. entsprechen 8 mg des wöchentlichen Depotpräparats, kein Dosisäquivalent für monatliches Depotpräparat; 8–10 mg/12–16 mg/18–24 mg s.l. entsprechen jeweils 16 mg/24 mg/32 mg des wöchentlichen, bzw. 64 mg/96 mg/128 mg des monatlichen Depotpräparats; bei einer oralen Dosierung von 26–32 mg direkte Umstellung auf 160 mg monatliches Depotpräparat möglich
Therapievorschlag: Initial Buprenorphin 4 mg s.l. als Verträglichkeitstest, anschließend in 1. Behandlungswoche 16 mg s.c., ggf. zusätzlich bei Entzugssymptomen 1–2 8-mg-Dosen s.c. mit einem Mindestabstand von 1 Tag; Zieldosis in 1. Behandlungswoche: 24–32 mg; ab der 2. Behandlungswoche Verabreichung der Gesamtdosis der 1. Behandlungswoche; nach stabiler Einstellung auf wöchentliches Depotpräparat (i.d.R. nach mind. 4 Wochen) Umstellung auf monatliches Depotpräparat gemäß folgender Dosisumrechnung möglich: 16 mg/24 mg/32 mg des wöchentlichen Depotpräparats entsprechen jeweils 64 mg/96 mg/128 mg des monatlichen Depotpräparats
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