Clozapin
Rezeptpflichtig
Tabletten Kurzübersicht
Erwachsene
Standarddosierung
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DANI
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DALI
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Ältere Personen
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Wichtige Hinweise
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Rote-Hand-Briefe
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Schwangerschaft / Stillzeit
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Kinder und Jugendliche
Zulassung
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Darreichungsformen
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Wichtige Hinweise
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Relevante Links
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Dosierung
Therapievorschlag: Clozapin initial 12,5 mg p.o. 1–2×/d, an Tag 2 25 mg p.o. 1–2×/d, anschließend bei guter Verträglichkeit schrittweise Erhöhung der Tagesdosis um 25–50 mg auf max. 300 mg/d innerhalb von 2–3 Wochen; bei Bedarf weitere halbwöchentliche oder vorzugsweise wöchentliche Erhöhung der Tagesdosis schrittweise um 50–100 mg mit einer Zieldosis von 200–450 mg/d, verteilt auf mehrere Einzelgaben; Maximaldosis: 900 mg/d; Kontraindikationen und Nebenwirkungen beachten
Clozapin 12,5 mg/d p.o. als abendliche Einzelgabe, langsame Dosissteigerung in 12,5-mg-Schritten möglich, Tagesmaximaldosis: 50 mg (im Ausnahmefall: 100 mg)
Therapievorschlag: Clozapin initial 6,25–12,5 mg/d p.o. als abendliche Einmalgabe, ggf. weitere schrittweise Erhöhung der Tagesdosis um 12,5 mg mit max. 2 Erhöhungen pro Woche, Erhaltungsdosis 25–37,5 mg/d, Maximaldosis 50 mg/d, bei Nicht-Ausreichen von 50 mg/d in Ausnahmefällen weitere Dosissteigerung um 12,5 mg/Woche auf bis zu 100 mg/d, vorsichtige Anwendung bei Leberfunktionsstörung, kontraindiziert bei schwerer Niereninsuffizienz, weitere Kontraindikationen und Nebenwirkungen beachten
Therapievorschlag: Clozapin initial 12,5 mg/d p.o. als abendliche Einmaldosis, Dosiserhöhungen (max. 2/Woche) in möglichst kleinen Schritten bis auf 50 mg/d möglich, in Ausnahmefällen kann bei ungenügender Wirksamkeit weiter langsam auf eine Tagesmaximaldosis von 100 mg gesteigert werden, Kontraindikationen und Nebenwirkungen beachten
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