Eplerenon
Rezeptpflichtig
Filmtabletten Kurzübersicht
Erwachsene
DANI
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DALI
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Ältere Personen
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Wichtige Hinweise
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Kinder und Jugendliche
Dosierung
Therapievorschlag: Eplerenon (z.B. Inspra®, Eplerenon AbZ®) 25 mg p.o. 1-0-0, Steigerung nach 4–8 Wochen auf 50 mg p.o. 1-0-0 bei guter Verträglichkeit, ab GFR <30 mL/min kontraindiziert, bei GFR 30–50 mL/min Dosisreduktion auf 25 mg 1-0-0 sowie regelmäßige Kontrollen des Serum-Kaliums erforderlich; CAVE: Eplerenon darf nicht zusammen mit CYP3A4-Inhibitoren (z.B. Clarithromycin) verabreicht werden!
Therapievorschlag (Off-Label Use): Eplerenon (z.B. Inspra®) 50 mg 1×/d p.o.; bei guter Verträglichkeit Steigerung auf 100 mg 1×/d nach 4–8 Wochen möglich; niedrigste wirksame Dosis anstreben; kontraindiziert bei eGFR <30 mL/min oder Serumkalium >5,0 mmol/L
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