Olanzapin
Rezeptpflichtig
Schmelztabletten, Filmtabletten, Pulver und Lösungsmittel zur Herst.einer Depot-Injektionssus, Trockensubstanz mit Loesungsmittel, Tabletten, Ueberzogene Tabletten, Pulver zur Herstellung einer Injektionsloesung Kurzübersicht
Erwachsene
Standarddosierung
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DANI
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DALI
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Ältere Personen
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Wichtige Hinweise
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Schwangerschaft / Stillzeit
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Kinder und Jugendliche
Dosierung
Therapievorschlag: Olanzapin (z.B. Zyprexa®) initial 10 mg/d p.o. als abendliche Einmalgabe; ggf. im Verlauf Dosiserhöhung in Abständen von >24 h, Erhaltungsdosis: 5–20 mg/d als abendliche Einmalgabe; bei älteren Personen (>65 Jahre): Dosisreduktion mit inital 5 mg/d, wenn klinische Gründe dafür vorliegen; bei Nieren- und Leberinsuffizienz: Reduktion der Anfangsdosis auf 5 mg/d; bei mittelgradiger Leberinsuffizienz zudem Dosiserhöhung nur mit größter Vorsicht!
Therapievorschlag: Olanzapin (z.B. Zyprexa®) bei Monotherapie initial 15 mg/d als abendliche Einmalgabe; bei Kombinationstherapie initial 10 mg/d, ggf. im Verlauf Dosiserhöhung in Abständen von >24 h, Erhaltungsdosis: 5–20 mg/d als abendliche Einmalgabe; bei älteren Personen (>65 Jahre): Dosisreduktion mit inital 5 mg/d, wenn klinische Gründe dafür vorliegen
Therapievorschlag: Olanzapin (z.B. Zyprexa velotab®) initial 10 mg i.m., ggf. wiederholte Gabe von 5–10 mg nach 2 h, Tagesmaximaldosis 20 mg, max. 3 Injektionen/d, bei Leber- und/oder Niereninsuffizienz oder bei einem Alter >60 Jahre Dosisreduktion auf 5 mg
Therapievorschlag: Olanzapin (z.B. Zyprexa®) initial 10–20 mg oral, Tagesmaximaldosis 10–40 mg
Therapievorschlag: Olanzapin initial 10 mg p.o. als Schmelztablette, Wirkeintritt abwarten, ggf. erneute Gabe nach 60 min, alternativ Olanzapin initial 5–10 mg i.m., Wirkeintritt abwarten, ggf. erneute Gabe nach 120 min. Beachte: Möglichst vor erster Gabe und bei längerer Gabe auch im Verlauf EKG-Kontrollen zur Überwachung einer möglichen QT-Zeit-Verlängerung durchführen.
Therapievorschlag laut Leitlinien: Olanzapin 5–10 mg p.o. 1×/Tag, keine Dosisanpassung bei Niereninsuffizienz erforderlich, Dosisanpassung bei Leberinsuffizienz nach Fachinformation
Therapievorschlag Olanzapin (z.B. Zyprexa®) initial 10 mg/d 0-0-1, ggf. im Verlauf Dosiserhöhung in Schritten von 5–10 mg und in Abständen von mind. 24 h, Erhaltungsdosis: 5–20 mg/d als Einmalgabe abends, Maximaldosis: 40 mg/d; Bei Älteren (>65 Jahre) initiale Dosisreduktion auf 5 mg/d; bei leichter bis mittelschwerer Leber- und/oder Niereninsuffizienz Reduktion der Anfangsdosis auf 5 mg/d; Dosisanpassung bei verringerter oder verstärkter CYP1A2-Aktivität
Therapievorschlag: Olanzapin (z.B. Zyprexa®) initial 2,5–5 mg i.m., Wiederholung alle 30 min möglich, Tagesmaximaldosis 20 mg. Anwendung bis zu 3 Tage, dann Umstellung auf orale Gabe: Olanzapin initial 10–20 mg/Tag p.o.; Cave: Keine Kombination mit Benzodiazepinen empfohlen!
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